Superdave1962
Dayton
I would say Ubuntu with either gnome or Mate is your best bet as mentioned by the other commentor. That being said, you could also take a look at PopOS with the new cosmic desktop environment. Supposedly there has been a lot of work focus on accessibility in that distribution. No experience with it myself though. And also, be aware, during the transition from the old ex Windows manager to the new Wayland has created several annoying issues/limitations with orca while they try and get it caught up.  
Jose Alberto
Either one works very well, but if you want stability, Ubuntu is the best. If you want constant updates, go with Fedora
Ruchir
Yes, orca is mandatory 
Dayton
Do you need to run the screen reader or orca, or any other assistive technologies?